Chemistry Graduate and Undergraduate Assistant Professor
office: MSRC 238
laboratory: MSRC 2-31/32
office phone: 787-523-5326
social media: proteinnmrgroup
-Protein structure and dynamics
-Biomolecular solid-state NMR
-HIV structure and assembly
-Nanoparticles and bionanomaterials
Our group studies biomolecular assemblies and interactions using solution and solid-state NMR spectroscopy. We are interested in HIV proteins and their structural mechanisms in virion formation, maturation, and their inhibition. In addition, we implement state-of-the-art spectroscopic methods to understand protein-protein and protein-drug interactions related to human disease and therapeutic strategies.
We also develop NMR-based techniques to characterize polymer assemblies designed for carbon capture and to elucidate biomineralization mechanisms. This biomimetic nanomaterials project is a DOE-funded collaboration with Pacific Northwest National Laboratory (https://www.pnnl.gov/publications/mimicking-nature-store-carbon-dioxide-minerals)
Cruz-Collazo A, Ruiz-Calderon JF, Picon H, Borrero-Garcia LD, Lopez I, Castillo-Pichardo L, Del Mar Maldonado M, Duconge J, Medina JI, Bayro MJ, Hernández-O’Farrill E, Vlaar CP, Dharmawardhane S. (2021) “Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer.” Mol Cancer Ther. 20, 2420-2432. PMCID: PMC8643341.
Purslow JA, Khatiwada B, Bayro MJ, Venditti V. “NMR Methods for Structural Characterization of Protein-Protein Complexes.” Front Mol Biosci (2020) 7, 9.
Vega-Figueroa K, Santillán J, Ortíz-Gómez V, Ortiz-Quiles E, Quiñones-Colón BA, Castilla- Casadiego DA; Almodovar J, Bayro MJ, Rodríguez-Martínez JA, Nicolau E. “Aptamer-based Impedimetric Assay of Arsenite in Water: Interfacial Properties and Performance.” ACS Omega (2018) 3, 1437-1444.
Bayro MJ, Ganser-Pornillos B, Yeager M, Tycko R. “Helical conformation in the CA-SP1 junctions of the immature HIV-1 lattice determined from solid-state NMR of virus-like particles.” J Am Chem Soc (2016) 138, 12029-12032.
Bayro MJ, Tycko R. “Structure of the dimerization interface in the mature HIV-1 capsid protein lattice from solid state NMR of tubular assemblies.” J Am Chem Soc (2016) 138, 8538- 8546. Featured in JACS Highlights.
Lu JX, Bayro MJ, Tycko R. “Major variations in HIV-1 capsid assembly morphologies involve minor variations in molecular structures of structurally ordered protein segments” J Biol Chem (2016) 291, 13098-13112.
Bayro MJ, Chen B, Yau WM, Tycko R. “Structural variations accompanying tubular assembly of the HIV-1 capsid protein.” J Mol Biol (2014) 426, 1109-1127.