Arthur D. Tinoco



profesor Arthur D Tinoco Banos

Chemistry Graduate and Undergraduate Assistant professor
Office Location: Facundo Bueso 312
Office Phone: 787-764-0000 ext. 88566
Lab Phone: 787-764-0000 ext. 88566

Social Networks
Twitter: @TeamTinoco

Research Interests
– Bioinorganic Chemistry
– Chemical Biological approaches to understand biomolecular regulation of metals
– Metals in Biology
– Studying small molecule mimics of metal-based enzymes
– Development of new drug design strategies for metal-based therapeutics
– Peptide-based drug delivery systems
– Mass spectrometry based ‘omics’ studies for elucidating the mechanism of action of
– Metal-based anticoronavirus drug development

Gaur, K.; Cruz, Y.M.; Santiago Espinoza, J.A.; Morales Rueda, C.A.; Loza-Rosas, S.A.; Fernandez-Vega, L.; Benjamin-Rivera, J.A.; Alvarez, A.; Tinoco, A.D. “Exploring the pH dependent aqueous speciation of metal complexes through UV-Vis spectroscopy.” J. Chem. Ed. 2020, doi: 10.1021/acs.jchemed.9b01199.

Hanif, M.; Yang, X., Tinoco, A.D.; and Plażuk, D. “Editorial: New Strategies in Design and Synthesis of Inorganic Pharmaceuticals.” Front. Chem. 2020, 8:453. doi: 10.3389/fchem.2020.00453.

Fernandez-Vega, L.; Ruiz Silva, V.A.; Domínguez-González, T.M.; Claudio-Betancourt, S.; Toro-Maldonado, R.E.; Capre Maso, L.C.; Sanabria Ortiz, K.; Pérez-Verdejo, J.A.; Román González, J.; Rosado-Fraticelli, G.T.; Pagán Meléndez, F.; Betancourt Santiago, F.M.; Rivera-Rivera, D.A.; Martínez Navarro, C.; Bruno Chardón, A.C. Vera, A.O.; Tinoco, A.D. “Evaluating ligand modifications of the titanocene and auranofin moieties for the development of more potent anticancer drugs.” Inorganics. 2020, 8, doi: 10.3390/inorganics8020010.

Sharma, S.; Sharma, R.K.; Gaur, K.; Cátala Torres, J.F.; Loza-Rosas, S.A.; Torres, A.; Saxena, M.; Julin, M. Tinoco, A.D. “Fueling a hot debate on the application of TiO2 nanoparticles in sunscreen.” Materials. 2019, 12, doi: 10.3390/ ma12142317.

Gaur, K.; Vazquez-Salgado, A.M.; Duran-Camacho, G.; Dominguez-Martinez; Benjamin-Rivera, J.A.; Fernandez-Vega, L.; Carmona Sarabia, L.; Cruz Garcia, A.; Perez-Deliz, F.; Mendez Roman, J.A.; Vega-Cartagena, M.; Loza-Rosas, S.A.; Rodriguez Acevedo, X.; Tinoco, A.D. “Iron and copper intracelular chelation as an anticancer drug strategy.” Inorganics. 2018, 6, doi: 10.3390/inorganics6040126.

Das, S.; Parga, K.; Chakraborty, I.; Tinoco, A.D.; Delgado, Y.; Lopez, P.M.; Fernández Vega, L.; Sanakis, Y.; Ghosh, Y.; Ghosh, S.; Bankson, J.; Klostergaard, J.; Gonzalez-Mendez, R.; Raptis, R.G. “Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents.” J. Inorg. Biochem. 2018, 186, 176-186.

Carballeira, N.M.; Morales-Guzman, C.; Alvarez-Benedicto, E.; Torres-Martinez, Z.; Delgado, Y.; Griebenow, K.; Tinoco, A.D.; Reguera, R.M.; Perez-Pertejo, Y.; Carbajo-Andres, R.; Balana-
Fouce, R. “First total synthesis of ω-phenyl ∆6 fatty acids and their Leishmanicidal and anticancer properties.” Curr. Top. Med. Chem. 2018, doi: 10.2174/1568026618666180516125056.

Saxena, M.; Delgado, Y.; Sharma, R.; Sharma, S.; Guzman, S.; Tinoco, A.D.; Griebenow, K.H. “Inducing cell death in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate.” PLoS ONE. 2018, 13(4): e0195542. doi: 10.1371/journal.pone.0195542.

Saxena, M.; Loza-Rosas, S.A.; Gaur, K.; Sharma, S.; Perez Otero, S.C.; Tinoco, A.D. “Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body.” Coord. Chem. Rev. 2018, 363, 109-125.

Loza-Rosas, S.A.; Vazquez, A.M.; Rivero, K.I.; Negron, L.J.; Delgado, Y.; Benjamin-Rivera, J.A.; Vazquez-Maldonado, A.L.; Parks, T.B.; Munet-Colon, C.; Tinoco, A.D. “Expanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti(IV) anticancer complexes.” Inorg. Chem. 2017, 56, 7788-7802.

Loza-Rosas, S.A.; Saxena, M.; Delgado, Y.; Gaur, K.; Pandrala, M.; Tinoco, A.D. “Ubiquitous metal, Difficult to track: Towards an understanding of the bioactivity of Titanium(IV) in humans.” Metallomics, 2017, 9, 346-356.

Morales-Cruz, M.; Cruz-Montañez, A.; Figueroa, C.M.; González-Robles, T.; Davila, J.; Inyushin, M.; Loza-Rosas, S.A.; Molina, A.M.; Muñoz-Perez, L.; Kucheryavykh, L.Y.; Tinoco, A.D.; Griebenow, K. “Combining stimulus-triggered release and active targetting strategies improves cytotoxicity of cytochrome c nanoparticles in tumor cells.” Mol. Pharmaceutics, 2016, 13, 2844-2854.

Tinoco, A.D.; Saxena, M.; Sharma, S.; Noinaj, N.; Delgado, Y.; Quiñones González, E.P.;
Conklin, S.E.; Zambrana, N.; Loza-Rosas, S.A.; Parks, T.B. “Unusual synergism of transferrin and
citrate in the regulation of Ti(IV) speciation, transport, and toxicity.” J. Amer. Chem. Soc., 2016,
138, 5659.

Saxena, M.; Sharma, R.K.; Ramirez, J.; Tinoco, A.D.; Griebenow, K. “A novel pro-apoptotic activity of a fungal cytochrome c from Rhizopus arrhizus.” BMC Biochemistry, 2015, 16, 21.

Parks, T.B.; Cruz, Y.M.; Tinoco, A.D. “Applying the Fe(III) binding property of a chemical transferrin mimetic to Ti(IV) anticancer drug design.” Inorg. Chem., 2014, 53, 1743.

Mitchell, A.; Lone, A.M.; Tinoco, A.D.; Saghatelian, A. “Proteolysis controls endogenous substance P levels.” PLOS ONE, 2013, 8(7): e68638. doi:10.1371/journal.pone.0068638

Tinoco, A.D.; Thomas, H.R.; Incarvito, C.D.; Saghatelian, A.; Valentine, A.M. “Cytotoxicity of a Ti(IV) complex is independent of serum proteins.” Proc. Natl. Acad. Sci., 2012, 109, 5016.