Chemistry Graduate and Undergraduate Professor
Phone: (787) 908-6404
Structure-guided protein encapsulation
-relationship between protein structural dynamics and enzyme activity
-PEG modification of proteins
Research in our laboratory typically involves exploration of interdisciplinary subjects involving protein biochemistry as one main aspect. Specifically, we are working on (a) improving systems for the sustained release of protein drugs from biocompatible polymer micro- and nanospheres; (b) stabilizing proteins by covalent modification with glycans and polymers for various applications (e.g., formulation, devices); (c) non-aqueous enzymology to stereoselective synthesize drug precursor molecules; (d) immobilize enzymes on nano-structured or -sized devices in biosensor and fuel-cell applications; (e) nano-particulate protein powders in delivery applications; (f) develop novel experiments to improve student learning in general chemistry laboratories; (g) computational modeling of modified proteins; (h) relationship between enzyme glycosylation, dynamics, function, and stability; (i) stabilization of proteins at interfaces (e.g., those encountered in medical devices).