{"id":19156,"date":"2025-03-14T17:51:23","date_gmt":"2025-03-14T17:51:23","guid":{"rendered":"https:\/\/natsci.uprrp.edu\/idgene\/?page_id=19156"},"modified":"2025-03-14T17:55:24","modified_gmt":"2025-03-14T17:55:24","slug":"edgar-a-maldonado-ortiz-2023-2025","status":"publish","type":"page","link":"https:\/\/natsci.uprrp.edu\/idgene\/edgar-a-maldonado-ortiz-2023-2025\/","title":{"rendered":"Edgar A. Maldonado Ortiz (2023-2025)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"19156\" class=\"elementor elementor-19156\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4dc48b2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4dc48b2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-681b8c6\" data-id=\"681b8c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-77e944a elementor-invisible elementor-widget elementor-widget-image\" data-id=\"77e944a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"853\" src=\"https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-768x1024.jpg\" class=\"attachment-large size-large wp-image-19111\" alt=\"\" srcset=\"https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-768x1024.jpg 768w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-225x300.jpg 225w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-1152x1536.jpg 1152w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-1536x2048.jpg 1536w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/Edgar-A.-Maldonado-Ortiz-1-scaled.jpg 1920w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e181b1f elementor-widget elementor-widget-spacer\" data-id=\"e181b1f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-d167fa8 elementor-invisible\" data-id=\"d167fa8\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b3e2930 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b3e2930\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9d2af7f\" data-id=\"9d2af7f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5dd62ce elementor-widget elementor-widget-heading\" data-id=\"5dd62ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Home Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9d4212b\" data-id=\"9d4212b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf6566f elementor-widget__width-initial elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"bf6566f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6d4e869 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6d4e869\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6c3c597\" data-id=\"6c3c597\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfb377b elementor-widget elementor-widget-text-editor\" data-id=\"dfb377b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mentor\/s:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-18976d5\" data-id=\"18976d5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15b879a elementor-widget elementor-widget-text-editor\" data-id=\"15b879a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW100791855 BCX0\" lang=\"ES-PR\" xml:lang=\"ES-PR\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW100791855 BCX0\">Dr. Carmen L. Cadilla V\u00e1zquez<\/span><\/span><span class=\"EOP SCXW100791855 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335557856&quot;:16777215,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c4c49f9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c4c49f9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d3f47e0\" data-id=\"d3f47e0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-04c1d62 elementor-widget elementor-widget-text-editor\" data-id=\"04c1d62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW233550703 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW233550703 BCX0\">Project Title:<\/span><\/span><span class=\"EOP SCXW233550703 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1d0edb9\" data-id=\"1d0edb9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7bb56ac elementor-widget elementor-widget-text-editor\" data-id=\"7bb56ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><span class=\"TextRun SCXW165650879 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW165650879 BCX0\">TWIST1 and Its Basic Domain Mutants Binding Analysis to DNA by SELEX-seq<\/span><\/span><span class=\"EOP SCXW165650879 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6b8ed81 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6b8ed81\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0669a62\" data-id=\"0669a62\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d25cbc elementor-widget elementor-widget-text-editor\" data-id=\"8d25cbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW233550703 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW233550703 BCX0\">Project Title:<\/span><\/span><span class=\"EOP SCXW233550703 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-f4ddd4f\" data-id=\"f4ddd4f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f0d1991 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f0d1991\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW243502137 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243502137 BCX0\">We try to investigate the DNA-binding properties of the transcription factor TWIST1, a <\/span><span class=\"NormalTextRun SCXW243502137 BCX0\">bHLH<\/span><span class=\"NormalTextRun SCXW243502137 BCX0\"> transcription factor crucial for mesodermal and craniofacial development. Mutations in the basic domain of the protein causes genetic conditions such as <\/span><span class=\"NormalTextRun SCXW243502137 BCX0\">Seathre-Chotzen<\/span><span class=\"NormalTextRun SCXW243502137 BCX0\"> Syndrome and Sweeney-Cox Syndrome. Using SELEX-seq, we examined how wild-type TWIST1 and patient-derived basic domain mutants (R116L, R118H, R118L, E117G, E117V) recognize DNA motifs.<\/span><\/span><span class=\"EOP SCXW243502137 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32f7216 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32f7216\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9138b0a elementor-invisible\" data-id=\"9138b0a\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e23c068 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e23c068\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1bb63cd\" data-id=\"1bb63cd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0e3909 elementor-widget elementor-widget-heading\" data-id=\"b0e3909\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Summer Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4f2b9fc\" data-id=\"4f2b9fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c1828de elementor-widget__width-initial elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c1828de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cc22405 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cc22405\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-90b7b13\" data-id=\"90b7b13\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50564a1 elementor-widget elementor-widget-text-editor\" data-id=\"50564a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mentor\/s:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-92f5aca\" data-id=\"92f5aca\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89a3229 elementor-widget elementor-widget-text-editor\" data-id=\"89a3229\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW152180217 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW152180217 BCX0\">Dr. Carlos J. Camacho<\/span><\/span><span class=\"EOP SCXW152180217 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d1741b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d1741b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-45ea3c3\" data-id=\"45ea3c3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0534a72 elementor-widget elementor-widget-text-editor\" data-id=\"0534a72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW233550703 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW233550703 BCX0\">Project Title:<\/span><\/span><span class=\"EOP SCXW233550703 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b4f951e\" data-id=\"b4f951e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9779644 elementor-widget elementor-widget-text-editor\" data-id=\"9779644\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><span class=\"TextRun SCXW224249530 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW224249530 BCX0\">Exploring Optimality Principles in Bacteria and Human PTP1B Phosphatases<\/span><\/span><span class=\"EOP SCXW224249530 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335557856&quot;:16777215,&quot;335559738&quot;:225,&quot;335559739&quot;:225}\">\u00a0<\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3311b82 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3311b82\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-830aba4\" data-id=\"830aba4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-594af5d elementor-widget elementor-widget-text-editor\" data-id=\"594af5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW233550703 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW233550703 BCX0\">Project Title:<\/span><\/span><span class=\"EOP SCXW233550703 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-53f08d1\" data-id=\"53f08d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b27ce0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0b27ce0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW243803461 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243803461 BCX0\">For this project we intended to explore the catalytic efficiency differences between Yersinia PTP <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243803461 BCX0\">YopH<\/span><span class=\"NormalTextRun SCXW243803461 BCX0\"> and human PTP1B, two Protein Tyrosine Phosphatases (PTPs) involved in intracellular signaling. Using biochemical data and kinetic modeling with the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243803461 BCX0\">BioNetGen<\/span><span class=\"NormalTextRun SCXW243803461 BCX0\"> program, we <\/span><span class=\"NormalTextRun SCXW243803461 BCX0\">identified<\/span><span class=\"NormalTextRun SCXW243803461 BCX0\"> key factors contributing to <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243803461 BCX0\">YopH\u2019s<\/span><span class=\"NormalTextRun SCXW243803461 BCX0\"> significantly faster catalytic rate.<\/span><\/span><span class=\"EOP SCXW243803461 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-39c714c\" data-id=\"39c714c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5829c6d elementor-invisible elementor-widget elementor-widget-image\" data-id=\"5829c6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"633\" src=\"https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831-1024x1012.jpg\" class=\"attachment-large size-large wp-image-19169\" alt=\"\" srcset=\"https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831-1024x1012.jpg 1024w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831-300x296.jpg 300w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831-768x759.jpg 768w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831-1536x1518.jpg 1536w, https:\/\/natsci.uprrp.edu\/idgene\/wp-content\/uploads\/sites\/27\/2025\/03\/IMG_1895-scaled-e1741974778831.jpg 1680w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Home Research Mentor\/s: Dr. Carmen L. Cadilla V\u00e1zquez\u00a0 Project Title:\u00a0 TWIST1 and Its Basic Domain Mutants Binding Analysis to DNA by SELEX-seq\u00a0 Project Title:\u00a0 We try to investigate the DNA-binding properties of the transcription factor TWIST1, a bHLH transcription factor &hellip; <\/p>\n","protected":false},"author":58,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19156","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/pages\/19156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/users\/58"}],"replies":[{"embeddable":true,"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/comments?post=19156"}],"version-history":[{"count":11,"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/pages\/19156\/revisions"}],"predecessor-version":[{"id":19295,"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/pages\/19156\/revisions\/19295"}],"wp:attachment":[{"href":"https:\/\/natsci.uprrp.edu\/idgene\/wp-json\/wp\/v2\/media?parent=19156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}