{"id":1998,"date":"2020-04-20T18:12:01","date_gmt":"2020-04-20T18:12:01","guid":{"rendered":"http:\/\/natsci.uprrp.edu\/chemistry\/?page_id=1998"},"modified":"2025-03-25T17:54:03","modified_gmt":"2025-03-25T21:54:03","slug":"arthur-d-tinoco","status":"publish","type":"page","link":"https:\/\/natsci.uprrp.edu\/chemistry\/arthur-d-tinoco\/","title":{"rendered":"Dr. Arthur D. Tinoco"},"content":{"rendered":"\n

Chemistry Graduate and Undergraduate Professor<\/strong>
e-mail: arthur.tinoco@upr.edu
Office Location: Facundo Bueso 312
Office Phone: 787-764-0000 ext. 88566
Lab Location: Facundo Bueso 136 & 143
Lab Phone: 787-764-0000 ext. 88566
Homepage: http:\/\/tinocolab.weebly.com\/ <\/a><\/p>\n\n\n\n

Social Networks<\/strong>
Twitter: @TeamTinoco<\/p>\n\n\n\n

Research Interests<\/strong>
– Bioinorganic Chemistry
– Chemical Biological approaches to understand biomolecular regulation of metals
– Metals in Biology
– Studying small molecule mimics of metal-based enzymes
– Development of new drug design strategies for metal-based therapeutics
– Peptide-based drug delivery systems
– Mass spectrometry based \u2018omics\u2019 studies for elucidating the mechanism of action of
therapeutics
– Metal-based anticoronavirus drug development
– To promote and encourage disability, gender, race, sexual orientation, and socioeconomic status diversity in the Natural Sciences and to create spaces and opportunities for inclusivity in the STEM workforce.
– To study the metal bioactivity in humans and to elucidate the molecular mechanisms that regulate this behavior.
– To develop new bio-inspired drug design strategies for metal-based therapeutics and use mass spectrometry based \u201comics\u201d studies to investigate the mechanism of action of these compounds for improved target selectivity.<\/p>\n\n\n\n

Research Objectives<\/strong>
Projects<\/em><\/strong><\/p>\n\n\n\n

    \n
  1. Protein regulation of metal functionality and therapeutic potential<\/li>\n\n\n\n
  2. Using peptides for selective metal delivery<\/li>\n\n\n\n
  3. Synergizing titanium(IV) and iron chelators in an anticancer drug design strategy to attack the bioavailability of iron in cancer cells<\/li>\n\n\n\n
  4. With the emergency of the COVID-19 pandemic, the Tinoco laboratory will be embarking on a mission to apply the functional tunability of metal-protein interactions for the development of a specific drug against SARS-COV-2. To this end, we will explore the development of albumin-fatty acid-metal complexes operate in a multimodal fashion to attack SARS-COV-2 and inhibit its aggressive spreading.<\/li>\n\n\n\n
  5. NSF REU: PR-CLIMB<\/a><\/li>\n<\/ol>\n\n\n\n

    Publications<\/strong>
    https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/arthur.tinoco.1\/bibliography\/public\/<\/a><\/p>\n\n\n\n

    Rodr\u00edguez, I.; Fern\u00e1ndez-Vega, L.; Maser-Figueroa, A.N.; Sang, B.; Gonz\u00e1lez-Pag\u00e1n, P.; Tinoco, A.D.*<\/strong> \u201cExploring Titanium(IV) Complexes as Potential Antimicrobial Compounds.\u201d Antibiotics<\/em> 2022<\/strong>, 11<\/em>, 158. https:\/\/doi.org\/10.3390\/antibiotics11020158<\/a><\/p>\n\n\n\n

    Delinois, L.J.; De Leon-Velez, O.; Vazquez-Medina, A.; Velez-Cabrera, A.; Marrero-Sanchez, A.; Nieves-Escobar, C.; Alfonso-Cano, D.; Caraballo-Rodriguez, D.; Rodriguez-Ortiz, J.; Acosta-Mercado, J.; Benjamin-Rivera, J.A.; Gonzalez-Gonzalez, K.; Fernandez-Adorno, K.; Santiago-Pagan, L.; Delgado-Vergara, R.; Torres-Avila, X.; Maser-Figueroa, A.; Grajales-Aviles, G.; Miranda Mendez, G.I.; Santiago-Pagan, J.; Nieves-Santiago, M.; Alvarez-Carrillo, V.; Griebenow, K.; Tinoco, A.D.<\/strong>* \u201cCytochrome c: Using biological insight toward engineering an optimized anticancer biodrug.\u201d Inorganics <\/em>2021<\/strong>, 9, 83. https:\/\/doi.org\/10.3390\/inorganics9110083<\/a>.<\/p>\n\n\n\n

    Gaur, K.; Perez Otero, S.C.; Benjamin-Rivera, J.A.; Rodriguez, I.; Loza-Rosas, S.A.; Vazquez-Salgado, A.M.; Akam, E.A.; Hernandez-Matias, L.; Sharma, R.K.; Alicea, N.; Kowaleff, M.; Washington, A.V.; Astashkin, A.V.; Tomat, E.; Tinoco, A.D.<\/strong>* \u201cIron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase.\u201d J. Am. Chem. Soc. Au. <\/em>2021<\/strong>, doi:10.1021\/jacsau.1c00078<\/a><\/p>\n\n\n\n

    Rodriguez, I.*; Gautam, R.*; Tinoco, A.D.*<\/strong> \u201cUsing X-ray diffraction techniques for biomimetic drug development, formulation, and polymorphic characterization.\u201d Biomimetics.<\/em> 2021<\/strong>, doi: 10.3390\/biomimetics6010001<\/a>.<\/p>\n\n\n\n

    Delinois, L.J.; Peon, H.; Villalobos-Santos, J.C.; Ramirez-Paz, J.; Miller, J.; Griebenow, K.H.; Tinoco, A.D.* <\/strong>\u201cA cytochrome c-chlorotoxin hybrid protein as a possible antiglioma drug.\u201d ChemMedChem. <\/em>2020<\/strong>, 15(22)<\/em>, 2185-2192.<\/p>\n\n\n\n

    Benjamin-Rivera, J.A.; Cardona-Rivera, A.E.; Vazquez-Maldonado, A.L.; Dones-Lassalle, C.Y.; Pabon-Colon, H.L.; Rodriguez-Rivera, H.M.; Rodriguez, I.; Gonzalez-Espiet, J.C.; Catala-Torres, J.F.; Carrasquillo Rivera, M.; De Jesus-Soto, M.G.; Cordero-Virella, N.C.; Cruz-Maldonado, P.M.; Gonzalez-Pagan, P.; Hernandez-Rios, R.; Gaur, K.; Loza-Rosas, S.A.; Tinoco, A.D.*<\/strong> \u201cExploring serum transferrin regulation of nonferric metal therapeutic function and toxicity.\u201d Inorganics.<\/em> 2020<\/strong>, 8<\/em>(9), 48; doi: 10.3390\/inorganics8090048.<\/p>\n\n\n\n

    Gaur, K.; Cruz, Y.M.; Santiago Espinoza, J.A.; Morales Rueda, C.A.; Loza-Rosas, S.A.; Fernandez-Vega, L.; Benjamin-Rivera, J.A.; Alvarez, A.; Tinoco, A.D.* <\/strong>\u201cExploring the pH dependent aqueous speciation of metal complexes through UV-Vis spectroscopy.\u201d J. Chem. Ed. <\/em>2020<\/strong>, doi: 10.1021\/acs.jchemed.9b01199.<\/p>\n\n\n\n

    Hanif, M.*; Yang, X., Tinoco, A.D.<\/strong>; and Pla\u017cuk, D. \u201cEditorial: New Strategies in Design and Synthesis of Inorganic Pharmaceuticals.\u201d Front. Chem. <\/em>2020, <\/strong>8:453. doi: 10.3389\/fchem.2020.00453.<\/p>\n\n\n\n

    Fernandez-Vega, L.; Ruiz Silva, V.A.; Dom\u00ednguez-Gonz\u00e1lez, T.M.; Claudio-Betancourt, S.; Toro-Maldonado, R.E.; Capre Maso, L.C.; Sanabria Ortiz, K.; P\u00e9rez-Verdejo, J.A.; Rom\u00e1n Gonz\u00e1lez, J.; Rosado-Fraticelli, G.T.; Pag\u00e1n Mel\u00e9ndez, F.; Betancourt Santiago, F.M.; Rivera-Rivera, D.A.; Mart\u00ednez Navarro, C.; Bruno Chard\u00f3n, A.C. Vera, A.O.; Tinoco, A.D.*<\/strong> \u201cEvaluating ligand modifications of the titanocene and auranofin moieties for the development of more potent anticancer drugs.\u201d Inorganics.<\/em> 2020<\/strong>, 8<\/em>, doi: 10.3390\/inorganics8020010.<\/p>\n\n\n\n

    Sharma, S.; Sharma, R.K.; Gaur, K.; C\u00e1tala Torres, J.F.; Loza-Rosas, S.A.; Torres, A.; Saxena, M.; Julin, M. Tinoco, A.D.<\/strong>* \u201cFueling a hot debate on the application of TiO2<\/sub> nanoparticles in sunscreen.\u201d Materials.<\/em> 2019<\/strong>, 12<\/em>, doi: 10.3390\/ ma12142317.<\/p>\n\n\n\n

    Gaur, K.; Vazquez-Salgado, A.M.; Duran-Camacho, G.; Dominguez-Martinez; Benjamin-Rivera, J.A.; Fernandez-Vega, L.; Carmona Sarabia, L.; Cruz Garcia, A.; Perez-Deliz, F.; Mendez Roman, J.A.; Vega-Cartagena, M.; Loza-Rosas, S.A.; Rodriguez Acevedo, X.; Tinoco, A.D.<\/strong>* \u201cIron and copper intracelular chelation as an anticancer drug strategy.\u201d Inorganics.<\/em> 2018<\/strong>, 6<\/em>, doi: 10.3390\/inorganics6040126.<\/p>\n\n\n\n

    Das, S.; Parga, K.; Chakraborty, I.; Tinoco, A.D.<\/strong>; Delgado, Y.; Lopez, P.M.; Fern\u00e1ndez Vega, L.; Sanakis, Y.; Ghosh, Y.; Ghosh, S.; Bankson, J.; Klostergaard, J.; Gonzalez-Mendez, R.; Raptis, R.G.* \u201cMagnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents.\u201d J. Inorg. Biochem<\/em>. 2018<\/strong>, 186<\/em>, 176-186.<\/p>\n\n\n\n

    Carballeira, N.M.*; Morales-Guzman, C.; Alvarez-Benedicto, E.; Torres-Martinez, Z.; Delgado, Y.; Griebenow, K.; Tinoco, A.D.<\/strong>; Reguera, R.M.; Perez-Pertejo, Y.; Carbajo-Andres, R.; Balana-Fouce, R. \u201cFirst total synthesis of \u03c9-phenyl \u22066 fatty acids and their Leishmanicidal and anticancer properties.\u201d Curr. Top. Med. Chem<\/em>. 2018<\/strong>, doi: 10.2174\/1568026618666180516125056.<\/p>\n\n\n\n

    Saxena, M.; Delgado, Y.; Sharma, R.; Sharma, S.; Guzman, S.; Tinoco, A.D.<\/strong>; Griebenow, K.H.* \u201cInducing cell death in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate.\u201d PLoS ONE<\/em>. 2018<\/strong>, 13(4): e0195542. doi: 10.1371\/journal.pone.0195542.<\/p>\n\n\n\n

    Saxena, M.; Loza-Rosas, S.A.; Gaur, K.; Sharma, S.; Perez Otero, S.C.; Tinoco, A.D.<\/strong>* \u201cExploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body.\u201d Coord. Chem. Rev<\/em>. 2018<\/strong>, 363<\/em>, 109-125.<\/p>\n\n\n\n

    Loza-Rosas, S.A.; Vazquez, A.M.; Rivero, K.I.; Negron, L.J.; Delgado, Y.; Benjamin-Rivera, J.A.; Vazquez-Maldonado, A.L.; Parks, T.B.; Munet-Colon, C.; Tinoco, A.D.<\/strong>* \u201cExpanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti(IV) anticancer complexes.\u201d Inorg. Chem<\/em>. 2017<\/strong>, 56<\/em>, 7788-7802.<\/p>\n\n\n\n

    Loza-Rosas, S.A.; Saxena, M.; Delgado, Y.; Gaur, K.; Pandrala, M.; Tinoco, A.D.<\/strong>* \u201cA ubiquitous metal, Difficult to track: Towards an understanding of the bioactivity of Titanium(IV) in humans.\u201d Metallomics<\/em>, 2017<\/strong>, 9<\/em>, 346-356.<\/p>\n\n\n\n

    Morales-Cruz, M.; Cruz-Monta\u00f1ez, A.; Figueroa, C.M.; Gonz\u00e1lez-Robles, T.; Davila, J.; Inyushin, M.; Loza-Rosas, S.A.; Molina, A.M.; Mu\u00f1oz-Perez, L.; Kucheryavykh, L.Y.; Tinoco, A.D.<\/strong>; Griebenow, K. \u201cCombining stimulus-triggered release and active targetting strategies improves cytotoxicity of cytochrome c nanoparticles in tumor cells.\u201d Mol. Pharmaceutics<\/em>, 2016<\/strong>, 13<\/em>, 2844-2854.<\/p>\n\n\n\n

    Tinoco, A.D.<\/strong>*; Saxena, M.; Sharma, S.; Noinaj, N.; Delgado, Y.; Qui\u00f1ones Gonz\u00e1lez, E.P.;
    Conklin, S.E.; Zambrana, N.;  Loza-Rosas, S.A.; Parks, T.B. \u201cUnusual synergism of transferrin and
    citrate in the regulation of Ti(IV) speciation, transport, and toxicity.\u201d  J. Amer. Chem. Soc.<\/em>, 2016<\/strong>,
    138<\/strong>, 5659.<\/p>\n\n\n\n

    Saxena, M.; Sharma, R.K.; Ramirez, J.; Tinoco, A.D.<\/strong>; Griebenow, K.* \u201cPurification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus<\/em>.\u201d BMC Biochemistry<\/em>, 2015<\/strong>, 16<\/em>, 21.<\/p>\n\n\n\n

    Parks, T.B.; Cruz, Y.M.; Tinoco, A.D.*<\/strong> \u201cApplying the Fe(III) binding property of a chemical transferrin mimetic to Ti(IV) anticancer drug design.\u201d Inorg. Chem.<\/em>, 2014<\/strong>, 53<\/em>, 1743.<\/p>\n\n\n\n

    Mitchell, A.; Lone, A.M.; Tinoco, A.D.*;<\/strong> Saghatelian, A.* \u201cProteolysis controls endogenous substance P levels.\u201d PLOS ONE<\/em>, 2013<\/strong>, 8(7): e68638. doi:10.1371\/journal.pone.0068638<\/p>\n\n\n\n

    Tinoco, A.D.*<\/strong>; Thomas, H.R.; Incarvito, C.D.; Saghatelian, A.; Valentine, A.M. \u201cCytotoxicity of a Ti(IV) complex is independent of serum proteins.\u201d Proc<\/em>. Natl. Acad. Sci.<\/em>, 2012<\/strong>, 109<\/em>, 5016.<\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Chemistry Graduate and Undergraduate Professore-mail: arthur.tinoco@upr.eduOffice Location: Facundo Bueso 312Office Phone: 787-764-0000 ext. 88566Lab Location: Facundo Bueso 136 & 143Lab Phone: 787-764-0000 ext. 88566Homepage: http:\/\/tinocolab.weebly.com\/  Social NetworksTwitter: @TeamTinoco Research Interests– Bioinorganic Chemistry– Chemical Biological approaches to understand biomolecular regulation of metals– Metals in Biology– Studying small molecule mimics of metal-based … <\/p>\n","protected":false},"author":23,"featured_media":2766,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1998","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=1998"}],"version-history":[{"count":12,"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1998\/revisions"}],"predecessor-version":[{"id":3303,"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1998\/revisions\/3303"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/media\/2766"}],"wp:attachment":[{"href":"https:\/\/natsci.uprrp.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=1998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}