Invitación a oportunidades de investigación y aplicación al programa MD/PhD UIC
El viernes 4 de noviembre de 2016 a la 1:00pm tendremos la visita de la Sra. Denise Yates y de la Dra. Tolou Shokuhfar, que nos estarán orientando sobre las oportunidades de investigación sub-graduada para este próximo verano de 2017 en UI Chicago; además tendremos la conferencia científica titulada:Nanotechnology Innovations for Medical Implants; y al finalizar, una orientación de cómo aplicar a escuela graduada y al programa MD/PhD.
Nanotechnology Innovations for Medical Implants
Tolou Shokuhfar, PhD
Director, In situ Nanomedicine Laboratory
Department of Bioengineering, University of Illinois at Chicago, USA
Future prospects for nanotechnology and biomaterials in medical applications appear to be excellent. In orthopedic applications, there is a significant need and demand for the development of a bone implant that is bioactive and exhibits mechanical and surface properties comparable with those of natural, healthy bone. This need arises from the fact that in 2009, $17.2 billion was spent on approximately 1.1 million joint replacement surgeries. The number of such procedures is forecast to be 3.8 million per year by 2030 with corresponding rise in cost burden. This sharp increase stems from an aging population as well as the more frequent use of orthopedic implants in the treatment of severe degenerative and arthritic conditions. Implant failure, either directly or indirectly, is most often caused by loosening (osteolysis) at the bone-prosthesis interface. Implant loosening is the major complication in total joint replacement. Currently, the only option available for countering loosened implant is revision surgery that presents additional clinical challenges due to complexity of the procedure as well as compromised osteogenic local environment due to osteolysis related events. A more attractive and effective approach is to enhance bone regeneration around the implant at the earlier stages to yield higher fixation strength and longevity. Therefor, there is a significant need and demand for the development of a bone implant that is bioactive and exhibits mechanical and surface properties comparable with those of natural, healthy bone. We have successfully modified the surface of orthopedic and dental implants with TiO2nanotubes that exhibit the ability to mimic the dimensions of constituent components of natural bone. We have shown implants modified by TiO2 nanotubes promote osteointegration and can be a successful alternative to conventional implants. In addition, medical implants such as orthopedic, dental, pacemakers, and vascular stents may require subsequent drug therapy regiments to prevent infection, or decrease inflammation. Drug release derived directly from the implant surface rather than systemically can reduce unnecessary side effects and increase efficiency. TiO2 nanotube textured implants not only can promise to enhance osseointegration but also can fight infection and eliminate chronic inflammation and provide a clinical benefit for a broad range of implant-needing patients.
Dr. Tolou Shokuhfar, research focuses on (1) in-situ liquid electron microscopy of biomolecules and biomaterials and their biochemical activities in wet/hydrated environment for diagnostic of human diseases; (2) smart and multifunctional nanobiomaterials. She has received the National Science Foundation’s most prestigious awards (NSF CAREER Award) which is given to junior faculties who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations. Dr. Shokuhfar is being named a recipient of the “2016 TMS FMD Young Leaders Professional Development Award”, the “DSL2014 Young Scientist Award”, and the national recognition of “INSIGHT Diversity 2015 Award for Inspiring Women in STEM Award”. She is currently advising 3 post-docs, 5 PhD students, and 4 master students, and has 60 archival publications including 2 book chapters, is ad hoc reviewer for more than 10 journals, presented 21 national and international invited talks, and 50 conference presentations. She is the Organizer of “Advanced Materials in Dental and Orthopedic Applications” Symposium at the TMS conference, and Symposium Organizer for “Biomedical Implants and Devices” at DSL International Conference. She currently holds 3 officer positions as Program Chair for Orthopedic Biomaterials, Treasurer for Nanomaterials at the Society for Biomaterials (SFB), and Guest editor of Journal Of Materials (JOM).