Professor Rodriguez’s work on Aplysqualenol A was published in Angew. Chem.
Together with his graduate student, Brunilda Vera (currently working as a postdoc at the Harbor Branch Oceanographic Institution in Florida) and his collaborator, Dr. James J. La?Clair, Professor Abimael D. Rodríguez published their recent breakthrough on Aplysqualenol?A in Angew. Chem, one of the top journals in chemistry.
In this study, they developed a bidirectional affinity system for the identification of cancer-related natural products and their biological targets. Aplysqualenol?A is thus selectively identified as a ligand of the dynein light chain. The use of forward and reverse affinity methods suggests that both small-molecule isolation and target identification can be conducted using conventional molecular biological methods.
Congrats, and we are looking forwards to more such exciting work!
For details, see Vera, B.; Rodriguez, A.D.; La Clair, J.J. “Aplysqualenol A Binds to the Light Chain of Dynein Type 1 (DYNLL1)” Angew. Chem. Int. Ed. 2011, 50, 8134-8138.