Professor Carballeira's review article was ranked as one of the Top-20 most cited articles
Professor Nestor Carballeiraâ€™s review article titledÂ
New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents
Published in Progress in Lipid Research (2008, 47, 50-61) is ranked as one of the Top-20 most cited articles published in this journal during the period 2008-2010.
Below is the abstract of this article
This review deals with the most recent findings on the antimalarial, antimycobacterial, and antifungal properties of fatty acids, with particular emphasis on novel marine fatty acids. The first section deals with the most recent and some background literature on what has been the latest developments with respect to fatty acids as antimalarial agents andÂ the importance of inhibiting the enoyl-ACP-reductase (FabI) ofÂ P. falciparum for antimalarial activity, the principal agent responsible for malaria.Â The second section of the paper deals with recent literature on the antimycobacterial activity of fatty acids and also the importance of enzyme inhibition, in particular the inhibition of the enoyl-ACP-reductase (InhA) ofÂ M. tuberculosis for antimycobacterial activity. The last part of the paper, the antifungal section, also emphasizes the most recent research with antifungal fatty acids and emphasizes the importance of N-myristoyltransferase (NMT) inhibition for antifungal activity.
Progress in Lipid Research is a leading journal (with an impact factor of 8.167) reviewing the most recent progress in lipids, one of the fundamental classes of biological compounds.